Version 5.4
Mus musculus Gene: Prex2
Summary
InnateDB Gene IDBG-133525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prex2
Gene Name phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms 6230420N16Rik; AI316880; AI553603; C030045D06Rik; D430013K02; Depdc2; P-Rex2
Species Mus musculus
Ensembl Gene ENSMUSG00000048960
Encoded Proteins
IDBP-133527
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
IDBP-787932
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
IDBP-787934
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
IDBP-787935
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
IDBP-787936
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000046889:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10993465-11303681
Strand Forward strand
Band A2
Transcripts
ENSMUST00000027056 ENSMUSP00000027056
ENSMUST00000190935
ENSMUST00000189822
ENSMUST00000187694
ENSMUST00000188189 ENSMUSP00000140621
ENSMUST00000187745 ENSMUSP00000140788
ENSMUST00000189385 ENSMUSP00000140863
ENSMUST00000188154 ENSMUSP00000140580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008344 adult locomotory behavior
GO:0032314 regulation of Rac GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000046889
View Gene Order
ENSBTAG00000022169
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 109294
UniGene
RefSeq NM_001033636 NM_029525
OMIM
CCDS CCDS48217
HPRD
IMGT
MGI ID MGI:1923385
MGI Symbol Prex2
EMBL
GenPept
RNA Seq Atlas 109294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca