Version 5.4
Homo sapiens Gene: PREX2
Summary
InnateDB Gene IDBG-24486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PREX2
Gene Name phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000046889
Encoded Proteins
IDBP-24488
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67952118-68237030
Strand Forward strand
Band q13.2
Transcripts
ENST00000288368 ENSP00000288368
ENST00000517617
ENST00000522247
ENST00000520235
ENST00000529398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008344 adult locomotory behavior
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0048813 dendrite morphogenesis
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048960
View Gene Order
ENSBTAG00000022169
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.169943 Hs.591867 Hs.731160 Hs.732080
RefSeq NM_024870 NM_025170
HUGO
OMIM
CCDS CCDS6201
HPRD 13135
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca