Version 5.4
Mus musculus Gene: Nkiras1
Summary
InnateDB Gene IDBG-133760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkiras1
Gene Name NFKB inhibitor interacting Ras-like protein 1
Synonyms 2400004O09Rik; kappaB-Ras1; KBRAS1
Species Mus musculus
Ensembl Gene ENSMUSG00000021772
Encoded Proteins
IDBP-133762
NFKB inhibitor interacting Ras-like protein 1
IDBP-535858
NFKB inhibitor interacting Ras-like protein 1
IDBP-540832
NFKB inhibitor interacting Ras-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15024091
[Homo sapiens] NKIRAS1, in both GDP-bound and GTP-bound states, inhibits phosphorylation of NFKBIB by IKBKB and makes it resistant to degradation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197885:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:18271136-18283942
Strand Forward strand
Band A2
Transcripts
ENSMUST00000022294 ENSMUSP00000022294
ENSMUST00000132374 ENSMUSP00000121496
ENSMUST00000133460 ENSMUSP00000122235
ENSMUST00000152735
ENSMUST00000150209
ENSMUST00000145355
ENSMUST00000156186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000197885
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WIJ8
UniProt Splice Variant
Entrez Gene 69721
UniGene Mm.25648
RefSeq XM_006518099 NM_023526 XM_006518097
OMIM
CCDS CCDS26836
HPRD
IMGT
MGI ID MGI:1916971
MGI Symbol Nkiras1
EMBL AC154489 CU024892
GenPept
RNA Seq Atlas 69721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca