Version 5.4
Homo sapiens Gene: NKIRAS1
Summary
InnateDB Gene IDBG-22073.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKIRAS1
Gene Name NFKB inhibitor interacting Ras-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197885
Encoded Proteins
IDBP-22075
NFKB inhibitor interacting Ras-like 1
IDBP-367698
NFKB inhibitor interacting Ras-like 1
IDBP-367704
NFKB inhibitor interacting Ras-like 1
IDBP-367711
NFKB inhibitor interacting Ras-like 1
IDBP-367725
NFKB inhibitor interacting Ras-like 1
IDBP-367728
NFKB inhibitor interacting Ras-like 1
IDBP-367733
NFKB inhibitor interacting Ras-like 1
IDBP-367741
NFKB inhibitor interacting Ras-like 1
IDBP-806432
NFKB inhibitor interacting Ras-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15024091
NKIRAS1, in both GDP-bound and GTP-bound states, inhibits phosphorylation of NFKBIB by IKBKB and makes it resistant to degradation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:23891660-23946591
Strand Reverse strand
Band p24.2
Transcripts
ENST00000388759 ENSP00000373411
ENST00000443659 ENSP00000393785
ENST00000421515 ENSP00000392307
ENST00000425478 ENSP00000400385
ENST00000437230 ENSP00000406543
ENST00000412028 ENSP00000396063
ENST00000415901 ENSP00000415225
ENST00000416026 ENSP00000394214
ENST00000614374 ENSP00000483749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000021772
View Gene Order
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.173202 Hs.685706
RefSeq NM_020345 XM_005265076 XM_005265078
HUGO
OMIM
CCDS CCDS33717
HPRD 06841
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca