Homo sapiens Gene: NTF3
Summary
InnateDB Gene IDBG-13412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTF3
Gene Name neurotrophin 3
Synonyms HDNF; NGF-2; NGF2; NT-3; NT3;
Species Homo sapiens
Ensembl Gene ENSG00000185652
Encoded Proteins
neurotrophin 3
neurotrophin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:5432112-5521536
Strand Forward strand
Band p13.31
Transcripts
ENST00000331010 ENSP00000328738
ENST00000423158 ENSP00000397297
ENST00000535299
ENST00000543548
ENST00000544836
ENST00000541234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005165 neurotrophin receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
GO:0048406 nerve growth factor binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0002092 positive regulation of receptor internalization
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007274 neuromuscular synaptic transmission
GO:0007399 nervous system development
GO:0007403 glial cell fate determination
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007422 peripheral nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0021675 nerve development
GO:0030335 positive regulation of cell migration
GO:0032148 activation of protein kinase B activity
GO:0032856 activation of Ras GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042490 mechanoreceptor differentiation
GO:0042552 myelination
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045687 positive regulation of glial cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048484 enteric nervous system development
GO:0048666 neuron development
GO:0048699 generation of neurons
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050804 regulation of synaptic transmission
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005576 extracellular region
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Role of erk5 in neuronal survival pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by the MAPK pathway
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.99171
RefSeq NM_001102654 NM_002527
HUGO
OMIM
CCDS CCDS44806 CCDS8538
HPRD 01219
IMGT
EMBL
GenPept
RNA Seq Atlas