Version 5.4
| Mus musculus Gene: Rps6ka2 | |||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-134649.6 | ||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
| Gene Symbol | Rps6ka2 | ||||||||||||||||||||||||||||||||
| Gene Name | ribosomal protein S6 kinase, polypeptide 2 | ||||||||||||||||||||||||||||||||
| Synonyms | 90kDa; D17Wsu134e; p90rsk; pp90rsk; Rps6ka-rs1; Rsk3 | ||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000023809 | ||||||||||||||||||||||||||||||||
| Encoded Proteins |
ribosomal protein S6 kinase, polypeptide 2
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| Protein Structure | |||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071242:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 17:7170115-7303313 | ||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||
| Band | A1 | ||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Signaling by GPCR pathway
Recycling pathway of L1 pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
ERK/MAPK targets pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
CREB phosphorylation through the activation of Ras pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Post NMDA receptor activation events pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Axon guidance pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
L1CAM interactions pathway
Signalling by NGF pathway
Neuronal System pathway
Developmental Biology pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Transmission across Chemical Synapses pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
RSK activation pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
MAPK signaling pathway pathway
Long-term potentiation pathway
mTOR signaling pathway pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
IL6 pathway
Leptin pathway
Prolactin pathway
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| REACTOME |
ERK/MAPK targets pathway
CREB phosphorylation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
RSK activation pathway
CREB phosphorylation through the activation of Ras pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
Cellular responses to stress pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Post NMDA receptor activation events pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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| KEGG |
mTOR signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||
| UniGene | Mm.268383 Mm.412422 | ||||||||||||||||||||||||||||||||
| RefSeq | NM_011299 XM_006523198 XM_006523199 XM_006523200 XM_006523201 | ||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||
| CCDS | CCDS28376 | ||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||