Bos taurus Gene: RPS6KA2
Summary
InnateDB Gene IDBG-635849.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA2
Gene Name ribosomal protein S6 kinase alpha-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021741
Encoded Proteins
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071242:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:102918982-103074109
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061538 ENSBTAP00000053410
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001556 oocyte maturation
GO:0002035 brain renin-angiotensin system
GO:0006468 protein phosphorylation
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0010659 cardiac muscle cell apoptotic process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0045835 negative regulation of meiosis
GO:0060047 heart contraction
GO:0070613 regulation of protein processing
GO:0071322 cellular response to carbohydrate stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
IL6 pathway
Leptin pathway
Prolactin pathway
REACTOME
RSK activation pathway
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation pathway
Neuronal System pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by GPCR pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Post NMDA receptor activation events pathway
Recycling pathway of L1 pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
ERK/MAPK targets pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Signaling by GPCR pathway
Recycling pathway of L1 pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
ERK/MAPK targets pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
CREB phosphorylation through the activation of Ras pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Post NMDA receptor activation events pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Axon guidance pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
L1CAM interactions pathway
Signalling by NGF pathway
Neuronal System pathway
Developmental Biology pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Transmission across Chemical Synapses pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
RSK activation pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
MAPK signaling pathway pathway
Oocyte meiosis pathway
mTOR signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
MAPK signaling pathway pathway
Oocyte meiosis pathway
mTOR signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MNR5
UniProt Splice Variant
Entrez Gene 517953
UniGene Bt.33477
RefSeq NM_001192478 XM_005211107 XM_005211108
HUGO HGNC:10431
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027503
GenPept
RNA Seq Atlas 517953
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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