Version 5.4
Mus musculus Gene: Cald1
Summary
InnateDB Gene IDBG-134865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cald1
Gene Name caldesmon 1
Synonyms 4833423D12Rik; AI195384; AV071549; AW536160; C920027I18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000029761
Encoded Proteins
IDBP-134867
caldesmon 1
IDBP-134871
caldesmon 1
IDBP-250507
caldesmon 1
IDBP-250509
caldesmon 1
IDBP-250513
caldesmon 1
IDBP-539935
caldesmon 1
IDBP-788596
caldesmon 1
IDBP-534631
caldesmon 1
IDBP-539449
caldesmon 1
IDBP-534677
caldesmon 1
IDBP-535263
caldesmon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122786:
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:34598500-34775473
Strand Forward strand
Band B1
Transcripts
ENSMUST00000079391 ENSMUSP00000078362
ENSMUST00000031775 ENSMUSP00000031775
ENSMUST00000115027 ENSMUSP00000110679
ENSMUST00000115026 ENSMUSP00000110678
ENSMUST00000115021 ENSMUSP00000110673
ENSMUST00000142512 ENSMUSP00000122926
ENSMUST00000155714
ENSMUST00000154182
ENSMUST00000127055
ENSMUST00000149009 ENSMUSP00000138368
ENSMUST00000123823 ENSMUSP00000117064
ENSMUST00000136907 ENSMUSP00000121213
ENSMUST00000126181 ENSMUSP00000121911
ENSMUST00000142716 ENSMUSP00000116247
ENSMUST00000146685
ENSMUST00000132331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0017022 myosin binding
Biological Process
GO:0006936 muscle contraction
GO:0006940 regulation of smooth muscle contraction
Cellular Component
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030478 actin cap
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122786
View Gene Order
ENSBTAG00000013953
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.308134 Mm.468134 Mm.468327 Mm.482600 Mm.486970
RefSeq NM_145575 XM_006505345 XM_006505346 XM_006505348 XM_006505349 XM_006505351 XM_006505352
OMIM
CCDS CCDS39456
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca