Version 5.4
Homo sapiens Gene: CALD1
Summary
InnateDB Gene IDBG-42284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALD1
Gene Name caldesmon 1
Synonyms CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Species Homo sapiens
Ensembl Gene ENSG00000122786
Encoded Proteins
IDBP-42286
caldesmon 1
IDBP-42290
caldesmon 1
IDBP-244247
caldesmon 1
IDBP-386487
caldesmon 1
IDBP-386489
caldesmon 1
IDBP-386491
caldesmon 1
IDBP-386493
caldesmon 1
IDBP-386494
caldesmon 1
IDBP-386496
caldesmon 1
IDBP-386499
caldesmon 1
IDBP-386501
caldesmon 1
IDBP-386502
caldesmon 1
IDBP-477528
caldesmon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:134744252-134970728
Strand Forward strand
Band q33
Transcripts
ENST00000361675 ENSP00000354826
ENST00000361901 ENSP00000354513
ENST00000393118 ENSP00000376826
ENST00000417172 ENSP00000398826
ENST00000436461 ENSP00000411476
ENST00000422748 ENSP00000395710
ENST00000454108 ENSP00000401988
ENST00000430085 ENSP00000394715
ENST00000445569 ENSP00000390926
ENST00000435928 ENSP00000416611
ENST00000443197 ENSP00000407522
ENST00000424922 ENSP00000393621
ENST00000475772
ENST00000462181
ENST00000482470
ENST00000498254
ENST00000489019
ENST00000495522 ENSP00000419673
ENST00000496024
ENST00000478075
ENST00000472096
ENST00000466704
ENST00000473714
ENST00000480638
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005523 tropomyosin binding
GO:0017022 myosin binding
Biological Process
GO:0006928 cellular component movement
GO:0006936 muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030016 myofibril
GO:0030478 actin cap
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029761
View Gene Order
ENSBTAG00000013953
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.490203 Hs.738084
RefSeq NM_004342 NM_033138 NM_033139 NM_033140 NM_033157 XM_006716136 XM_006716139
HUGO
OMIM
CCDS CCDS47716 CCDS47717 CCDS5834 CCDS5835 CCDS5836
HPRD 00251
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca