Version 5.4
Mus musculus Gene: Pfkfb3
Summary
InnateDB Gene IDBG-136298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfkfb3
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026773
Encoded Proteins
IDBP-136302
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-136304
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-136306
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-250900
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-250902
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-250904
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-624241
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-624242
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-719051
IDBP-789061
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170525:
Gene Information
Type Protein coding
Genomic Location Chromosome 2:11471430-11502101
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000028114 ENSMUSP00000028114
ENSMUST00000049849 ENSMUSP00000050926
ENSMUST00000100411 ENSMUSP00000097979
ENSMUST00000114846 ENSMUSP00000110495
ENSMUST00000114845 ENSMUSP00000110494
ENSMUST00000114844 ENSMUSP00000110493
ENSMUST00000150086
ENSMUST00000155167
ENSMUST00000140580
ENSMUST00000144921
ENSMUST00000145970
ENSMUST00000170196 ENSMUSP00000126305
ENSMUST00000171188 ENSMUSP00000129122
ENSMUST00000179584 ENSMUSP00000137130
ENSMUST00000183869 ENSMUSP00000138893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0007420 brain development
GO:0016311 dephosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170525
View Gene Order
ENSBTAG00000008401
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL A7UAK4
UniProt Splice Variant
Entrez Gene 170768
UniGene Mm.403577
RefSeq NM_001177752 NM_001177753 NM_001177754 NM_001177755 NM_001177756 NM_001177757 NM_001177758 NM_133232 XM_006497370
OMIM
CCDS CCDS50498 CCDS15683 CCDS50499 CCDS50500 CCDS50501
HPRD
IMGT
MGI ID MGI:2181202
MGI Symbol Pfkfb3
EMBL AL929179 EU034675
GenPept ABS88612
RNA Seq Atlas 170768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca