Version 5.4
Homo sapiens Gene: PFKFB3
Summary
InnateDB Gene IDBG-50922.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB3
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms IPFK2; PFK2
Species Homo sapiens
Ensembl Gene ENSG00000170525
Encoded Proteins
IDBP-50924
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-50926
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-50936
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-50938
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-50940
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-364435
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-364438
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-364442
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-585700
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-588338
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-602153
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-585131
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-583777
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
IDBP-595635
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:6144934-6235545
Strand Forward strand
Band p15.1
Transcripts
ENST00000379789 ENSP00000369115
ENST00000379785 ENSP00000369111
ENST00000317350 ENSP00000369105
ENST00000360521 ENSP00000353712
ENST00000379775 ENSP00000369100
ENST00000450232 ENSP00000390285
ENST00000414237 ENSP00000416677
ENST00000441697 ENSP00000404995
ENST00000490474 ENSP00000436885
ENST00000467491 ENSP00000434628
ENST00000477914 ENSP00000432356
ENST00000461744 ENSP00000433771
ENST00000487989
ENST00000475881 ENSP00000434342
ENST00000536985 ENSP00000443319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0007420 brain development
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026773
View Gene Order
ENSBTAG00000008401
Not yet available
Pathways
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.195471
RefSeq NM_001145443 NM_001282630 NM_004566 XM_005252463
HUGO
OMIM
CCDS CCDS44353 CCDS60479 CCDS7078
HPRD 05612
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca