Version 5.4
Mus musculus Gene: Klf10
Summary
InnateDB Gene IDBG-136307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf10
Gene Name Kruppel-like factor 10
Synonyms AI115143; EGR[a]; Egral; Gdnfif; mGIF; Tieg; TIEG-1; Tieg1
Species Mus musculus
Ensembl Gene ENSMUSG00000037465
Encoded Proteins
IDBP-136309
Kruppel-like factor 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155090:
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:38294413-38300707
Strand Reverse strand
Band B3.1
Transcripts
ENSMUST00000074043 ENSMUSP00000073690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030282 bone mineralization
GO:0035019 somatic stem cell maintenance
GO:0045672 positive regulation of osteoclast differentiation
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000155090
View Gene Order
ENSBTAG00000014396
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O89091
TrEMBL
UniProt Splice Variant
Entrez Gene 21847
UniGene
RefSeq NM_013692 XM_006520046 XM_006520047
OMIM
CCDS CCDS27438
HPRD
IMGT
MGI ID MGI:1101353
MGI Symbol Klf10
EMBL AF049879 AF049880 AF064088 BC003316
GenPept AAC16734 AAC77796 AAC77797 AAH03316
RNA Seq Atlas 21847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca