Version 5.4
Homo sapiens Gene: KLF10
Summary
InnateDB Gene IDBG-31363.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF10
Gene Name Kruppel-like factor 10
Synonyms EGR-alpha; EGRA; TIEG; TIEG1
Species Homo sapiens
Ensembl Gene ENSG00000155090
Encoded Proteins
IDBP-31365
Kruppel-like factor 10
IDBP-238657
Kruppel-like factor 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:102648779-102655902
Strand Reverse strand
Band q22.3
Transcripts
ENST00000285407 ENSP00000285407
ENST00000395884 ENSP00000379222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030282 bone mineralization
GO:0035019 somatic stem cell maintenance
GO:0045672 positive regulation of osteoclast differentiation
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037465
View Gene Order
ENSBTAG00000014396
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13118
TrEMBL
UniProt Splice Variant
Entrez Gene 7071
UniGene Hs.435001 Hs.600362
RefSeq NM_001032282 NM_005655
HUGO HGNC:11810
OMIM 601878
CCDS CCDS47905 CCDS6294
HPRD 03527
IMGT
EMBL AF050110 AK312894 AP002851 BC011538 BC095399 BT006634 CH471060 HF546210 HF546211 S81439 U21847
GenPept AAB36088 AAC34293 AAC34294 AAC50340 AAH11538 AAH95399 AAP35280 BAG35741 CCO02796 CCO02797 EAW91850
RNA Seq Atlas 7071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca