Version 5.4
Mus musculus Gene: Il17f
Summary
InnateDB Gene IDBG-136612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17f
Gene Name interleukin 17F
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041872
Encoded Proteins
IDBP-136614
interleukin 17F
IDBP-787654
interleukin 17F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25595775
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
InnateDB Annotation from Orthologs
Summary
PMID 19144317
[Homo sapiens] IL17A and IL17F are required for the induction of beta-defensin in vivo in mice.
PMID 19244213
[Homo sapiens] IL17F signalling inhibits expression of pro-inflammatory genes though sequential phosphorylation of CEBPB regulatory 2 domain.
PMID 21074482
[Homo sapiens] IL17F is a Th17-related cytokine, traditionally thought of as an adaptive responder, has been shown to have various innate sources and functions as a rapidly produced pro-inflammatory mediator. Innate IL17F-producing cells also employ many of the cytokine and transcriptional regulators utilized by Th17 cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112116:
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20777146-20790617
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000039046 ENSMUSP00000046960
ENSMUST00000191111
ENSMUST00000189301 ENSMUSP00000140122
ENSMUST00000190692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 7 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006029 proteoglycan metabolic process
GO:0006954 inflammatory response
GO:0016525 negative regulation of angiogenesis
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0042089 cytokine biosynthetic process
GO:0042109 lymphotoxin A biosynthetic process
GO:0045076 regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0045414 regulation of interleukin-8 biosynthetic process
GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051216 cartilage development
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112116
View Gene Order
ENSBTAG00000016835
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_145856 XM_006495522 XM_006495523
OMIM
CCDS CCDS35522
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca