InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL17F

Summary

InnateDB Gene

IDBG-90517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17F

Gene Name

interleukin 17F

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112116

Encoded Proteins

IDBP-90521

interleukin 17F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19144317

IL17A and IL17F are required for the induction of beta-defensin in vivo in mice.

PMID 19244213

IL17F signalling inhibits expression of pro-inflammatory genes though sequential phosphorylation of CEBPB regulatory 2 domain.

PMID 21074482

IL17F is a Th17-related cytokine, traditionally thought of as an adaptive responder, has been shown to have various innate sources and functions as a rapidly produced pro-inflammatory mediator. Innate IL17F-producing cells also employ many of the cytokine and transcriptional regulators utilized by Th17 cells.

InnateDB Annotation from Orthologs

Summary

PMID 25595775

[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52236681-52244537

Strand

Reverse strand

Band

p12.2

Transcripts

ENST00000336123	ENSP00000337432
ENST00000478427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006029	proteoglycan metabolic process
GO:0006954	inflammatory response
GO:0016525	negative regulation of angiogenesis
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0042089	cytokine biosynthetic process
GO:0042109	lymphotoxin A biosynthetic process
GO:0045076	regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045414	regulation of interleukin-8 biosynthetic process
GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:1900017	positive regulation of cytokine production involved in inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041872

View Gene Order

ENSBTAG00000016835

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

Q96PD4

TrEMBL

UniProt Splice Variant

Entrez Gene

112744

UniGene

Hs.272295

RefSeq

NM_052872

HUGO

HGNC:16404

OMIM

606496

CCDS

CCDS4938

HPRD

IMGT

EMBL

AF332389 AF384857 AL034343 BC070124

GenPept

AAH70124 AAK83350 AAL14427 CAD92646

RNA Seq Atlas

112744