Version 5.4
Mus musculus Gene: Fbxo18
Summary
InnateDB Gene IDBG-136862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo18
Gene Name F-box protein 18
Synonyms AU015756; Fbh1; Fbx18
Species Mus musculus
Ensembl Gene ENSMUSG00000058594
Encoded Proteins
IDBP-136866
F-box protein 18
IDBP-250961
F-box protein 18
IDBP-537306
F-box protein 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134452:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:11742573-11777582
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000071564 ENSMUSP00000071495
ENSMUST00000114813 ENSMUSP00000110461
ENSMUST00000139292
ENSMUST00000155604
ENSMUST00000123717
ENSMUST00000131893 ENSMUSP00000116392
ENSMUST00000136633
ENSMUST00000123723
ENSMUST00000126543
ENSMUST00000151862
ENSMUST00000151402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001934 positive regulation of protein phosphorylation
GO:0008150 biological_process
GO:0032508 DNA duplex unwinding
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134452
View Gene Order
ENSBTAG00000004147
Not yet available
Cross-References
SwissProt Q8K2I9
TrEMBL
UniProt Splice Variant
Entrez Gene 50755
UniGene Mm.24088
RefSeq NM_015792 XM_006497506 XM_006497507 XM_006497508 XM_006497509
OMIM
CCDS CCDS15688
HPRD
IMGT
MGI ID MGI:1354699
MGI Symbol Fbxo18
EMBL AF184275 AK003964 AK083118 BC004036 BC031393
GenPept AAF03151 AAH04036 AAH31393 BAB23095 BAC38767
RNA Seq Atlas 50755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca