Version 5.4
Bos taurus Gene: BT.20171
Summary
InnateDB Gene IDBG-637081.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20171
Gene Name F-box only protein 18
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004147
Encoded Proteins
IDBP-689077
F-box only protein 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134452:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:17650891-17690062
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005426 ENSBTAP00000005426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001934 positive regulation of protein phosphorylation
GO:0008152 metabolic process
GO:0032508 DNA duplex unwinding
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134452
View Gene Order
ENSMUSG00000058594
View Gene Order
Cross-References
SwissProt
TrEMBL F1MSG2
UniProt Splice Variant
Entrez Gene 534383
UniGene Bt.20171
RefSeq NM_001099063
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02035345
GenPept
RNA Seq Atlas 534383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca