Mus musculus Gene: Gnb4
Summary
InnateDB Gene IDBG-136870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnb4
Gene Name guanine nucleotide binding protein (G protein), beta 4
Synonyms 6720453A21Rik; G(beta)4;
Species Mus musculus
Ensembl Gene ENSMUSG00000027669
Encoded Proteins
guanine nucleotide binding protein (G protein), beta 4
guanine nucleotide binding protein (G protein), beta 4
guanine nucleotide binding protein (G protein), beta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114450:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:32580332-32616585
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000108234 ENSMUSP00000103869
ENSMUST00000155737 ENSMUSP00000121127
ENSMUST00000152901
ENSMUST00000144292
ENSMUST00000143588
ENSMUST00000184130 ENSMUSP00000138886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0021762 substantia nigra development
Cellular Component
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glucagon-type ligand receptors pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
Integration of energy metabolism pathway
Metabolism pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
GPCR ligand binding pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
KEGG
Chemokine signaling pathway pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Presynaptic function of Kainate receptors pathway
Transmembrane transport of small molecules pathway
G alpha (12/13) signalling events pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Prostacyclin signalling through prostacyclin receptor pathway
Glucagon signaling in metabolic regulation pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Glucagon-type ligand receptors pathway
G-protein activation pathway
Activation of Kainate Receptors upon glutamate binding pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Platelet homeostasis pathway
G alpha (z) signalling events pathway
Thromboxane signalling through TP receptor pathway
Transmission across Chemical Synapses pathway
ADP signalling through P2Y purinoceptor 1 pathway
G beta:gamma signalling through PLC beta pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal amplification pathway
Class B/2 (Secretin family receptors) pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_013531 XM_006535403 XM_006535404
OMIM
CCDS CCDS17297
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas