Version 5.4
Homo sapiens Gene: GNB4
Summary
InnateDB Gene IDBG-66267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB4
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114450
Encoded Proteins
IDBP-66269
guanine nucleotide binding protein (G protein), beta polypeptide 4
IDBP-482428
guanine nucleotide binding protein (G protein), beta polypeptide 4
IDBP-478059
guanine nucleotide binding protein (G protein), beta polypeptide 4
IDBP-477127
guanine nucleotide binding protein (G protein), beta polypeptide 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179399202-179451590
Strand Reverse strand
Band q26.33
Transcripts
ENST00000232564 ENSP00000232564
ENST00000466899 ENSP00000420066
ENST00000468623 ENSP00000419693
ENST00000465153
ENST00000497513 ENSP00000420606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0008219 cell death
GO:0021762 substantia nigra development
GO:0044281 small molecule metabolic process
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027669
View Gene Order
ENSBTAG00000002767
Not yet available
Pathways
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21340
GPCR ligand binding pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JD14
UniProt Splice Variant
Entrez Gene 59345
UniGene Hs.173030 Hs.639225
RefSeq NM_021629 XM_005247692 XM_006713721
HUGO HGNC:20731
OMIM 610863
CCDS CCDS3230
HPRD 09973
IMGT
EMBL AC007620
GenPept
RNA Seq Atlas 59345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca