Mus musculus Gene: Slc22a1
Summary
InnateDB Gene IDBG-136910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc22a1
Gene Name solute carrier family 22 (organic cation transporter), member 1
Synonyms Lx1; Oct1; Orct; Orct1;
Species Mus musculus
Ensembl Gene ENSMUSG00000023829
Encoded Proteins
solute carrier family 22 (organic cation transporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175003:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:12648874-12675838
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000024596 ENSMUSP00000024596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005277 acetylcholine transmembrane transporter activity
GO:0005329 dopamine transmembrane transporter activity
GO:0005333 norepinephrine transmembrane transporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0008513 secondary active organic cation transmembrane transporter activity
GO:0015075 ion transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006812 cation transport
GO:0006836 neurotransmitter transport
GO:0006855 drug transmembrane transport
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0015874 norepinephrine transport
GO:0034220 ion transmembrane transport
GO:0048241 epinephrine transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:1901374 acetate ester transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
SLC-mediated transmembrane transport pathway
Metabolism pathway
Abacavir transport and metabolism pathway
Abacavir transmembrane transport pathway
Transmembrane transport of small molecules pathway
Organic cation/anion/zwitterion transport pathway
Organic cation transport pathway
KEGG
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Neuronal System pathway
Organic cation transport pathway
Neurotransmitter Clearance In The Synaptic Cleft pathway
Norepinephrine Neurotransmitter Release Cycle pathway
Abacavir transmembrane transport pathway
Organic cation/anion/zwitterion transport pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Na+/Cl- dependent neurotransmitter transporters pathway
Abacavir transport and metabolism pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Organic cation/anion/zwitterion transport pathway
SLC-mediated transmembrane transport pathway
Transmembrane transport of small molecules pathway
Organic cation transport pathway
Abacavir transport and metabolism pathway
Metabolism pathway
Abacavir transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O08966
TrEMBL
UniProt Splice Variant
Entrez Gene 20517
UniGene Mm.594
RefSeq NM_009202
OMIM
CCDS CCDS28393
HPRD
IMGT
MGI ID MGI:108111
MGI Symbol Slc22a1
EMBL AF010259 AF481054 BC021651 U38652
GenPept AAB19097 AAC98884 AAH21651 AAM22157
RNA Seq Atlas 20517