InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc22a1

Summary

InnateDB Protein

IDBP-136912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a1

Protein Name

solute carrier family 22 (organic cation transporter), member 1

Synonyms

Lx1; Oct1; Orct; Orct1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024596

InnateDB Gene

IDBG-136910 (Slc22a1)

Protein Structure

UniProt Annotation

Function

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. {ECO:0000269PubMed:10216142, ECO:0000269PubMed:12176030}.

Subcellular Localization

Basolateral cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in liver, kidney and intestine. Weakly expressed in adrenals and in lacting mammary glands. {ECO:0000269PubMed:16381671, ECO:0000269PubMed:8854860}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005277	acetylcholine transmembrane transporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005333	norepinephrine transmembrane transporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0008513	secondary active organic cation transmembrane transporter activity
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006812	cation transport
GO:0006836	neurotransmitter transport
GO:0006855	drug transmembrane transport
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0015874	norepinephrine transport
GO:0034220	ion transmembrane transport
GO:0048241	epinephrine transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:1901374	acetate ester transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:108111

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08966

PhosphoSite