Homo sapiens Gene: CDH12
Summary
InnateDB Gene IDBG-13717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH12
Gene Name cadherin 12, type 2 (N-cadherin 2)
Synonyms CDHB
Species Homo sapiens
Ensembl Gene ENSG00000154162
Encoded Proteins
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:21750673-22853622
Strand Reverse strand
Band p14.3
Transcripts
ENST00000382254 ENSP00000371689
ENST00000504376 ENSP00000423577
ENST00000522262 ENSP00000428786
ENST00000521384
ENST00000517378
ENST00000518209
ENST00000521745
ENST00000520668
ENST00000619694 ENSP00000480493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Adherens junctions interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004061
HUGO
OMIM
CCDS CCDS3890
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas