Homo sapiens Gene: CDH12
Summary
InnateDB Gene IDBG-13717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH12
Gene Name cadherin 12, type 2 (N-cadherin 2)
Synonyms CDHB;
Species Homo sapiens
Ensembl Gene ENSG00000154162
Encoded Proteins
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
cadherin 12, type 2 (N-cadherin 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:21750673-22853622
Strand Reverse strand
Band p14.3
Transcripts
ENST00000382254 ENSP00000371689
ENST00000504376 ENSP00000423577
ENST00000522262 ENSP00000428786
ENST00000521384
ENST00000517378
ENST00000518209
ENST00000521745
ENST00000520668
ENST00000619694 ENSP00000480493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.113684
RefSeq NM_004061
HUGO
OMIM
CCDS CCDS3890
HPRD 11081
IMGT
EMBL
GenPept
RNA Seq Atlas