Mus musculus Gene: Mcph1
Summary
InnateDB Gene IDBG-137280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcph1
Gene Name microcephaly, primary autosomal recessive 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039842
Encoded Proteins
microcephaly, primary autosomal recessive 1
microcephaly, primary autosomal recessive 1
microcephaly, primary autosomal recessive 1
microcephaly, primary autosomal recessive 1
microcephaly, primary autosomal recessive 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147316:
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:18595131-18803189
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000039412 ENSMUSP00000037000
ENSMUST00000124910 ENSMUSP00000131698
ENSMUST00000153133
ENSMUST00000146819 ENSMUSP00000131616
ENSMUST00000133417 ENSMUSP00000121636
ENSMUST00000141244 ENSMUSP00000119267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0010468 regulation of gene expression
GO:0021987 cerebral cortex development
GO:0043549 regulation of kinase activity
GO:0046605 regulation of centrosome cycle
GO:0050727 regulation of inflammatory response
GO:0060348 bone development
GO:0060623 regulation of chromosome condensation
GO:0071539 protein localization to centrosome
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Cell Cycle pathway
M Phase pathway
Condensation of Prophase Chromosomes pathway
Mitotic Prophase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Condensation of Prophase Chromosomes pathway
Cell Cycle pathway
M Phase pathway
Mitotic Prophase pathway
Cell Cycle, Mitotic pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.235296 Mm.489363
RefSeq NM_173189
OMIM
CCDS CCDS22124
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas