InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcph1

Summary

InnateDB Protein

IDBP-137282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcph1

Protein Name

microcephaly, primary autosomal recessive 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037000

InnateDB Gene

IDBG-137280 (Mcph1)

Protein Structure

UniProt Annotation

Function

Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.

Disease Associations

Tissue Specificity

High levels of expression are found in the developing forebrain and, in particular, in the walls of the lateral ventricles. {ECO:0000269PubMed:12046007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0010468	regulation of gene expression
GO:0021987	cerebral cortex development
GO:0043549	regulation of kinase activity
GO:0046605	regulation of centrosome cycle
GO:0050727	regulation of inflammatory response
GO:0060348	bone development
GO:0060623	regulation of chromosome condensation
GO:0071539	protein localization to centrosome
GO:0097150	neuronal stem cell maintenance