Version 5.4
Mus musculus Gene: Spag6
Summary
InnateDB Gene IDBG-137396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag6
Gene Name sperm associated antigen 6
Synonyms PF16
Species Mus musculus
Ensembl Gene ENSMUSG00000022783
Encoded Proteins
IDBP-137398
sperm associated antigen 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077327:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:16753016-16829456
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000023468 ENSMUSP00000023468
ENSMUST00000154624
ENSMUST00000147539
ENSMUST00000151132
ENSMUST00000132033
ENSMUST00000125017
ENSMUST00000141835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0007283 spermatogenesis
GO:0030030 cell projection organization
GO:0030317 sperm motility
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005929 cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077327
View Gene Order
ENSBTAG00000033291
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31701 Mm.399278
RefSeq NM_015773
OMIM
CCDS CCDS27988
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca