InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIK1

Summary

InnateDB Gene

IDBG-1374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK1

Gene Name

glutamate receptor, ionotropic, kainate 1

Synonyms

EAA3; EEA3; GLR5; GluK1; GLUR5

Species

Homo sapiens

Ensembl Gene

ENSG00000171189

Encoded Proteins

IDBP-1376

glutamate receptor, ionotropic, kainate 1

IDBP-1378

glutamate receptor, ionotropic, kainate 1

IDBP-1380

glutamate receptor, ionotropic, kainate 1

IDBP-1382

glutamate receptor, ionotropic, kainate 1

IDBP-229478

glutamate receptor, ionotropic, kainate 1

IDBP-229480

glutamate receptor, ionotropic, kainate 1

IDBP-229482

glutamate receptor, ionotropic, kainate 1

IDBP-229484

glutamate receptor, ionotropic, kainate 1

IDBP-588658

glutamate receptor, ionotropic, kainate 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:29536933-29940033

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000327783	ENSP00000327687
ENST00000389124	ENSP00000373776
ENST00000389125	ENSP00000373777
ENST00000309434	ENSP00000311646
ENST00000399914	ENSP00000382798
ENST00000399913	ENSP00000382797
ENST00000399909	ENSP00000382793
ENST00000399907	ENSP00000382791
ENST00000472429
ENST00000535441	ENSP00000446326

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0006810	transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0030534	adult behavior
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0048266	behavioral response to pain
GO:0051899	membrane depolarization
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022935

View Gene Order

ENSBTAG00000034854

Not yet available

Pathways

NETPATH

REACTOME

REACT_21343

Activation of Na-permeable Kainate Receptors pathway

REACT_13685

Neuronal System pathway

REACT_21322

Ionotropic activity of Kainate Receptors pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21346

Activation of Ca-permeable Kainate Receptor pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E7ENK3 Q71UA3 Q9UNN1

UniProt Splice Variant

Entrez Gene

2897

UniGene

Hs.664641

RefSeq

XM_006723991 NM_000830 NM_175611 XM_005260942 XM_005260943 XM_005260944

HUGO

HGNC:4579

OMIM

138245

CCDS

CCDS33530 CCDS42913

HPRD

00693

IMGT

EMBL

AF107257 AF107259 AP000091 AP000236 AP000237 AP000238 AP000239

GenPept

AAD03059 AAD04931 BAA97452

RNA Seq Atlas

2897