InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRIK1

Summary

InnateDB Protein

IDBP-229484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK1

Protein Name

glutamate receptor, ionotropic, kainate 1

Synonyms

EAA3; EEA3; GLR5; GluK1; GLUR5;

Species

Homo sapiens

Ensembl Protein

ENSP00000382791

InnateDB Gene

IDBG-1374 (GRIK1)

Protein Structure

UniProt Annotation

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0006810	transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0030534	adult behavior
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0048266	behavioral response to pain
GO:0051899	membrane depolarization
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt