Version 5.4
Homo sapiens Gene: BLVRA
Summary
InnateDB Gene IDBG-13778.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLVRA
Gene Name biliverdin reductase A
Synonyms BLVR; BVR; BVRA
Species Homo sapiens
Ensembl Gene ENSG00000106605
Encoded Proteins
IDBP-13780
biliverdin reductase A
IDBP-294087
biliverdin reductase A
IDBP-373196
biliverdin reductase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:43758680-43807342
Strand Forward strand
Band p13
Transcripts
ENST00000265523 ENSP00000265523
ENST00000402924 ENSP00000385757
ENST00000424330 ENSP00000412005
ENST00000453612
ENST00000486984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004074 biliverdin reductase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0042167 heme catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001999
View Gene Order
ENSBTAG00000013414
Not yet available
Pathways
NETPATH
REACTOME
REACT_22297
Heme degradation pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000712 NM_001253823
HUGO
OMIM
CCDS CCDS5472
HPRD 11229
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca