InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BLVRA

Summary

InnateDB Protein

IDBP-294087.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLVRA

Protein Name

biliverdin reductase A

Synonyms

BLVR; BVR; BVRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000385757

InnateDB Gene

IDBG-13778 (BLVRA)

Protein Structure

UniProt Annotation

Function

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.

Subcellular Localization

Cytoplasm.

Disease Associations

Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. {ECO:0000269PubMed:19580635}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004074	biliverdin reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0042167	heme catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process