Mus musculus Gene: Rdh8
Summary
InnateDB Gene IDBG-137818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rdh8
Gene Name retinol dehydrogenase 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000053773
Encoded Proteins
retinol dehydrogenase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080511:
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:20818504-20826163
Strand Forward strand
Band A3
Transcripts
ENSMUST00000066387 ENSMUSP00000067662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006703 estrogen biosynthetic process
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Disease pathway
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3Z6W3
UniProt Splice Variant
Entrez Gene 235033
UniGene Mm.297661
RefSeq NM_001030290
OMIM
CCDS CCDS22884
HPRD
IMGT
MGI ID MGI:2685028
MGI Symbol Rdh8
EMBL AC166365
GenPept
RNA Seq Atlas 235033