Mus musculus Gene: Sra1
Summary
InnateDB Gene IDBG-138270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sra1
Gene Name steroid receptor RNA activator 1
Synonyms AA959952; Sra; Srap; Straa1; Strra1
Species Mus musculus
Ensembl Gene ENSMUSG00000006050
Encoded Proteins
steroid receptor RNA activator 1
steroid receptor RNA activator 1
steroid receptor RNA activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213523:
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:36666681-36679366
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000006209 ENSMUSP00000006209
ENSMUST00000173875 ENSMUSP00000133360
ENSMUST00000173482 ENSMUSP00000134589
ENSMUST00000173202
ENSMUST00000174125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0010861 thyroid hormone receptor activator activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097194 execution phase of apoptosis
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005831 steroid hormone aporeceptor complex
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0030529 ribonucleoprotein complex
GO:0031252 cell leading edge
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29058 Mm.484305
RefSeq NM_025291 NM_146085 XM_006525861
OMIM
CCDS CCDS29156 CCDS29157
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas