InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sra1

Summary

InnateDB Gene

IDBG-138270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sra1

Gene Name

steroid receptor RNA activator 1

Synonyms

AA959952; Sra; Srap; Straa1; Strra1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006050

Encoded Proteins

IDBP-138272

steroid receptor RNA activator 1

IDBP-622035

steroid receptor RNA activator 1

IDBP-622039

steroid receptor RNA activator 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213523:
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:36666681-36679366

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006209	ENSMUSP00000006209
ENSMUST00000173875	ENSMUSP00000133360
ENSMUST00000173482	ENSMUSP00000134589
ENSMUST00000173202
ENSMUST00000174125

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0010861	thyroid hormone receptor activator activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097194	execution phase of apoptosis
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005831	steroid hormone aporeceptor complex
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030529	ribonucleoprotein complex
GO:0031252	cell leading edge
GO:0045171	intercellular bridge

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000213523

View Gene Order

ENSBTAG00000001449

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29058 Mm.484305

RefSeq

NM_025291 NM_146085 XM_006525861

OMIM

CCDS

CCDS29156 CCDS29157

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas