InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sra1

Summary

InnateDB Protein

IDBP-622035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sra1

Protein Name

steroid receptor RNA activator 1

Synonyms

AA959952; Sra; Srap; Straa1; Strra1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133360

InnateDB Gene

IDBG-138270 (Sra1)

Protein Structure

UniProt Annotation

Function

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity). {ECO:0000250UniProtKB:Q9HD15}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q9HD15}. Cytoplasm {ECO:0000250UniProtKB:Q9HD15}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0010861	thyroid hormone receptor activator activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097194	execution phase of apoptosis
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005831	steroid hormone aporeceptor complex
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030529	ribonucleoprotein complex
GO:0031252	cell leading edge
GO:0045171	intercellular bridge