InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC45

Summary

InnateDB Gene

IDBG-1383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC45

Gene Name

cell division cycle 45 homolog (S. cerevisiae)

Synonyms

CDC45L; CDC45L2; PORC-PI-1

Species

Homo sapiens

Ensembl Gene

ENSG00000093009

Encoded Proteins

IDBP-1385

cell division cycle 45 homolog (S. cerevisiae)

IDBP-292493

cell division cycle 45 homolog (S. cerevisiae)

IDBP-292495

cell division cycle 45 homolog (S. cerevisiae)

IDBP-361910

cell division cycle 45 homolog (S. cerevisiae)

IDBP-361912

cell division cycle 45 homolog (S. cerevisiae)

IDBP-361915

cell division cycle 45 homolog (S. cerevisiae)

IDBP-361918

cell division cycle 45 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:19479459-19520612

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000263201	ENSP00000263201
ENST00000407835	ENSP00000385240
ENST00000404724	ENSP00000384978
ENST00000438587	ENSP00000397434
ENST00000455750	ENSP00000413138
ENST00000437685	ENSP00000405726
ENST00000428937	ENSP00000388280
ENST00000491520
ENST00000483431
ENST00000487669
ENST00000471470
ENST00000493724

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	36 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication