Version 5.4
Homo sapiens Protein: CDC45
Summary
InnateDB Protein IDBP-1385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC45
Protein Name cell division cycle 45 homolog (S. cerevisiae)
Synonyms CDC45L; CDC45L2; PORC-PI-1;
Species Homo sapiens
Ensembl Protein ENSP00000263201
InnateDB Gene IDBG-1383 (CDC45)
Protein Structure
UniProt Annotation
Function Required for initiation of chromosomal DNA replication.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 36 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000076 DNA replication checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR003874 CDC45 family
PFAM PF02724
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75419
PhosphoSite PhosphoSite-O75419
TrEMBL C9K087
UniProt Splice Variant
Entrez Gene 8318
UniGene Hs.742418
RefSeq NP_003495
HUGO HGNC:1739
OMIM 603465
CCDS CCDS13762
HPRD 09145
IMGT
EMBL AC000082 AC000087 AC000088 AF053074 AF062495 AF081535 AJ223728 AK293123 AK293338 AY358971 AY572790 BC006232 BC010022 BT006792 CH471176 CT841513
GenPept AAC27289 AAC67521 AAD08998 AAH06232 AAH10022 AAP35438 AAQ89330 AAS66985 BAG56675 BAG56854 CAA11530 CAJ86443 EAX03036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca