InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ube2l3

Summary

InnateDB Gene

IDBG-138347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2l3

Gene Name

ubiquitin-conjugating enzyme E2L 3

Synonyms

C79827; Ubce7; UbcM4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038965

Encoded Proteins

IDBP-138349

ubiquitin-conjugating enzyme E2L 3

IDBP-249060

ubiquitin-conjugating enzyme E2L 3

IDBP-249062

ubiquitin-conjugating enzyme E2L 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185651:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:17152013-17202649

Strand

Reverse strand

Band

Transcripts

ENSMUST00000090192	ENSMUSP00000087658
ENSMUST00000115700	ENSMUSP00000111364
ENSMUST00000115699	ENSMUSP00000111363
ENSMUST00000157013
ENSMUST00000122873

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0071383	cellular response to steroid hormone stimulus
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185651

View Gene Order

ENSBTAG00000013038

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

mmu05012

Parkinson's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05012

Parkinson's disease pathway

INOH

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3074 Mm.387382 Mm.402033 Mm.449832 Mm.466419

RefSeq

NM_009456 XM_001475449 XM_001477899 XM_006522004 XM_006542801 XM_006543769 XM_006543770

OMIM

CCDS

CCDS27997

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas