InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2l3

Summary

InnateDB Protein

IDBP-138349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2l3

Protein Name

ubiquitin-conjugating enzyme E2L 3

Synonyms

C79827; Ubce7; UbcM4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087658

InnateDB Gene

IDBG-138347 (Ube2l3)

Protein Structure

UniProt Annotation

Function

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0071383	cellular response to steroid hormone stimulus
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109240

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR006575 RWD domain
IPR008883 Ubiquitin E2 variant, N-terminal
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179
PF05773
PF05743

PRINTS

PIRSF

SMART

SM00591

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P68037