|Mus musculus Gene: Defb1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||defensin beta 1|
defensin beta 1
|Useful resources||Stemformatics EHFPI ImmGen|
Defb1 is upregulated in plasmacytoid dendritic cells and monocyte during viral challenge Defb1-deficient mice infected with mouse-adapted HK18 (influenza) lost weight earlier and died sooner than WT mice, suggesting that Defb1 plays a role in early innate immune responses against influenza in vivo. However, lung virus titers were equal between the two mouse strains, indicating that the mechanism is not related to viral replication.
Defb1 is a component of platelets that displays classic antimicrobial activity and signals polymorphonuclear leukocytes to extrude DNA lattices that capture and kill bacteria. (Demonstrated in human)
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 8:21776599-21795185|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Beta defensins pathway
Innate Immune System pathway
Immune System pathway
|UniProt Splice Variant|
|EMBL||AA065510 AA071757 AA105324 AA107538 AA108061 AF003524 AF003525 AK142544 BC024380 CH466580|
|GenPept||AAB72003 AAH24380 BAE25100 EDL32923|
|RNA Seq Atlas||13214|