Mus musculus Gene: Defb1
Summary
InnateDB Gene IDBG-139170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb1
Gene Name defensin beta 1
Synonyms AW260221; BD-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000044748
Encoded Proteins
defensin beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Defb1 is upregulated in plasmacytoid dendritic cells and monocyte during viral challenge Defb1-deficient mice infected with mouse-adapted HK18 (influenza) lost weight earlier and died sooner than WT mice, suggesting that Defb1 plays a role in early innate immune responses against influenza in vivo. However, lung virus titers were equal between the two mouse strains, indicating that the mechanism is not related to viral replication.
Defb1 is a component of platelets that displays classic antimicrobial activity and signals polymorphonuclear leukocytes to extrude DNA lattices that capture and kill bacteria. (Demonstrated in human)
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:21776599-21795185
Strand Forward strand
Band A2
Transcripts
ENSMUST00000051017 ENSMUSP00000051754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002227 innate immune response in mucosa
GO:0002526 acute inflammatory response
GO:0006952 defense response
GO:0009617 response to bacterium
GO:0019731 antibacterial humoral response
GO:0033574 response to testosterone
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Defensins pathway
Beta defensins pathway
Innate Immune System pathway
Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P56386
TrEMBL Q3UQE2
UniProt Splice Variant
Entrez Gene 13214
UniGene Mm.456266
RefSeq NM_007843
OMIM
CCDS CCDS40282
HPRD
IMGT
MGI ID MGI:1096878
MGI Symbol Defb1
EMBL AA065510 AA071757 AA105324 AA107538 AA108061 AF003524 AF003525 AK142544 BC024380 CH466580
GenPept AAB72003 AAH24380 BAE25100 EDL32923
RNA Seq Atlas 13214