Version 5.4
Mus musculus Protein: Defb1
Summary
InnateDB Protein IDBP-139172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb1
Protein Name defensin beta 1
Synonyms AW260221; BD-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000051754
InnateDB Gene IDBG-139170 (Defb1)
Protein Structure
UniProt Annotation
Function Has bactericidal activity. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in kidney. {ECO:0000269PubMed:10922379}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002227 innate immune response in mucosa
GO:0002526 acute inflammatory response
GO:0006952 defense response
GO:0009617 response to bacterium
GO:0019731 antibacterial humoral response
GO:0033574 response to testosterone
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1096878
InterPro IPR001855 Beta defensin type
PFAM PF00711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56386
PhosphoSite PhosphoSite-
TrEMBL Q3UQE2
UniProt Splice Variant
Entrez Gene 13214
UniGene Mm.456266
RefSeq NP_031869
MGI ID
MGI Symbol Defb1
OMIM
CCDS CCDS40282
HPRD
IMGT
EMBL AA065510 AA071757 AA105324 AA107538 AA108061 AF003524 AF003525 AK142544 BC024380 CH466580
GenPept AAB72003 AAH24380 BAE25100 EDL32923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca