Mus musculus Gene: Alg11
Summary
InnateDB Gene IDBG-139624.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alg11
Gene Name asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063362
Encoded Proteins
asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000253710:
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22060721-22071627
Strand Forward strand
Band A2
Transcripts
ENSMUST00000072572 ENSMUSP00000072382
ENSMUST00000110737 ENSMUSP00000106365
ENSMUST00000131624 ENSMUSP00000119161
ENSMUST00000134474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0097502 mannosylation
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q3TZM9
TrEMBL
UniProt Splice Variant
Entrez Gene 207958
UniGene Mm.267439 Mm.400831 Mm.409856 Mm.446082 Mm.451887 Mm.489240
RefSeq NM_183142 NM_001243161 XM_006509045
OMIM
CCDS CCDS40292 CCDS57613
HPRD
IMGT
MGI ID MGI:2142632
MGI Symbol Alg11
EMBL AK046475 AK157746 BC061469
GenPept AAH61469 BAC32746 BAE34179
RNA Seq Atlas 207958