Homo sapiens Gene: LATS2
Summary
InnateDB Gene IDBG-13987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LATS2
Gene Name LATS, large tumor suppressor, homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150457
Encoded Proteins
LATS, large tumor suppressor, homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:20973032-21061547
Strand Reverse strand
Band q12.11
Transcripts
ENST00000382592 ENSP00000372035
ENST00000472754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 168 [view]
Protein-Protein 167 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0009755 hormone-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 regulation of organ growth
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644552 Hs.78960
RefSeq NM_014572 XM_005266342
HUGO
OMIM
CCDS CCDS9294
HPRD 07277
IMGT
EMBL
GenPept
RNA Seq Atlas