Mus musculus Gene: Lats2
Summary
InnateDB Gene IDBG-168883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lats2
Gene Name large tumor suppressor 2
Synonyms 4932411G09Rik; AV277261; AW228608;
Species Mus musculus
Ensembl Gene ENSMUSG00000021959
Encoded Proteins
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
large tumor suppressor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150457:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:57642077-57758388
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000022531 ENSMUSP00000022531
ENSMUST00000038381 ENSMUSP00000038982
ENSMUST00000077981 ENSMUSP00000077130
ENSMUST00000174694 ENSMUSP00000133680
ENSMUST00000174213 ENSMUSP00000134321
ENSMUST00000173990 ENSMUSP00000133976
ENSMUST00000173964 ENSMUSP00000134142
ENSMUST00000174166 ENSMUSP00000133379
ENSMUST00000173732 ENSMUSP00000133857
ENSMUST00000173077
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0009755 hormone-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 regulation of organ growth
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL Q8VHE1
UniProt Splice Variant
Entrez Gene 50523
UniGene Mm.347899 Mm.406989 Mm.408428
RefSeq NM_015771 NM_153382 XM_006519223 XM_006519224 XM_006519225
OMIM
CCDS CCDS27158 CCDS49508
HPRD
IMGT
MGI ID MGI:1354386
MGI Symbol Lats2
EMBL AC154504 AY015062
GenPept AAK07726
RNA Seq Atlas 50523