Version 5.4
Mus musculus Gene: Il2
Summary
InnateDB Gene IDBG-140190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il2
Gene Name interleukin 2
Synonyms Il-2
Species Mus musculus
Ensembl Gene ENSMUSG00000027720
Encoded Proteins
IDBP-140192
interleukin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26187413
[Homo sapiens] Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109471:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37120523-37125959
Strand Reverse strand
Band B
Transcripts
ENSMUST00000029275 ENSMUSP00000029275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 4 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0008083 growth factor activity
GO:0030246 carbohydrate binding
GO:0031851 kappa-type opioid receptor binding
GO:0043208 glycosphingolipid binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002903 negative regulation of B cell apoptotic process
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045582 positive regulation of T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046013 regulation of T cell homeostatic proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051024 positive regulation of immunoglobulin secretion
GO:0060999 positive regulation of dendritic spine development
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000109471
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04940
Type I diabetes mellitus pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05330
Allograft rejection pathway
mmu05332
Graft-versus-host disease pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04940
Type I diabetes mellitus pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05332
Graft-versus-host disease pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
il2_1pathway
IL2-mediated signaling events
il27pathway
IL27-mediated signaling events
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il12_stat4pathway
IL12 signaling mediated by STAT4
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
il23pathway
IL23-mediated signaling events
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
il2_pi3kpathway
IL2 signaling events mediated by PI3K
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P04351
TrEMBL Q546X1 Q91Y89
UniProt Splice Variant
Entrez Gene 16183
UniGene Mm.14190
RefSeq NM_008366
OMIM
CCDS CCDS17316
HPRD
IMGT
MGI ID MGI:96548
MGI Symbol Il2
EMBL AF065914 AF195956 AF399982 AF542383 AF542384 AL662823 K02292 L07574 L07576 M16760 M16761 M16762 X01663 X01664 X01665 X01772 X66058
GenPept AAA39281 AAA39289 AAA39326 AAA39328 AAD25890 AAF32272 AAK91717 AAN77288 AAN77289 CAA25823 CAA25824 CAA25825 CAA25909 CAA46854 CAM18418
RNA Seq Atlas 16183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca