InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL2

Summary

InnateDB Gene

IDBG-36892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2

Gene Name

interleukin 2

Synonyms

IL-2; lymphokine; TCGF

Species

Homo sapiens

Ensembl Gene

ENSG00000109471

Encoded Proteins

IDBP-36894

interleukin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26187413

Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

Entrez Gene

Summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:122451470-122456725

Strand

Reverse strand

Band

q27

Transcripts

ENST00000226730	ENSP00000226730
ENST00000477645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	17 [view]
Protein-DNA	33 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005134	interleukin-2 receptor binding
GO:0008083	growth factor activity
GO:0019209	kinase activator activity
GO:0030246	carbohydrate binding
GO:0031851	kappa-type opioid receptor binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002903	negative regulation of B cell apoptotic process
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0030101	natural killer cell activation
GO:0030217	T cell differentiation
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0034105	positive regulation of tissue remodeling
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0045591	positive regulation of regulatory T cell differentiation
GO:0045822	negative regulation of heart contraction
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046013	regulation of T cell homeostatic proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051024	positive regulation of immunoglobulin secretion
GO:0060999	positive regulation of dendritic spine development
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand