Homo sapiens Gene: IL2
Summary
InnateDB Gene IDBG-36892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2
Gene Name interleukin 2
Synonyms IL-2; lymphokine; TCGF;
Species Homo sapiens
Ensembl Gene ENSG00000109471
Encoded Proteins
interleukin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.
Entrez Gene
Summary The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:122451470-122456725
Strand Reverse strand
Band q27
Transcripts
ENST00000226730 ENSP00000226730
ENST00000477645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 17 [view]
Protein-DNA 33 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0008083 growth factor activity
GO:0019209 kinase activator activity
GO:0030246 carbohydrate binding
GO:0031851 kappa-type opioid receptor binding
GO:0043208 glycosphingolipid binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002903 negative regulation of B cell apoptotic process
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0030101 natural killer cell activation
GO:0030217 T cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0034105 positive regulation of tissue remodeling
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045582 positive regulation of T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046013 regulation of T cell homeostatic proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051024 positive regulation of immunoglobulin secretion
GO:0060999 positive regulation of dendritic spine development
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
IL2 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Chagas disease (American trypanosomiasis) pathway
Autoimmune thyroid disease pathway
Allograft rejection pathway
Graft-versus-host disease pathway
INOH
PID BIOCARTA
The 41bb-dependent immune response [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
IL2-mediated signaling events
IL27-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
IL23-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Regulation of Telomerase
Cross-References
SwissProt P60568
TrEMBL Q0GK43 Q309Q7 Q71V48 Q8NFA4 Q9C001
UniProt Splice Variant
Entrez Gene 3558
UniGene Hs.89679
RefSeq NM_000586
HUGO HGNC:6001
OMIM 147680
CCDS CCDS3726
HPRD
IMGT
EMBL AB451325 AB451454 AF031845 AF228636 AF359939 AF532913 BC066255 BC066257 BC070338 CH471056 DQ231169 DQ861285 J00264 K02056 M13879 M22005 M33199 S77834 S82692 V00564 X00695 X01586
GenPept AAA59139 AAA59140 AAA59141 AAA98792 AAB46883 AAB86861 AAD14263 AAD48509 AAG53575 AAH66255 AAH66257 AAH70338 AAK26665 AAM97916 ABB20900 ABI20697 BAG70139 BAG70268 CAA23827 CAA25292 CAA25742 EAX05227
RNA Seq Atlas 3558