Version 5.4
Mus musculus Gene: Gstk1
Summary
InnateDB Gene IDBG-141478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gstk1
Gene Name glutathione S-transferase kappa 1
Synonyms 0610025I19Rik; AW260476; DsbA-L
Species Mus musculus
Ensembl Gene ENSMUSG00000029864
Encoded Proteins
IDBP-141480
glutathione S-transferase kappa 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197448:
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42245935-42250441
Strand Forward strand
Band B2.1
Transcripts
ENSMUST00000031897 ENSMUSP00000031897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 95 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005102 receptor binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0030855 epithelial cell differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197448
View Gene Order
ENSBTAG00000009839
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00480
Glutathione metabolism pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00982
Drug metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00480
Glutathione metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt Q9DCM2
TrEMBL
UniProt Splice Variant
Entrez Gene 76263
UniGene
RefSeq NM_029555
OMIM
CCDS CCDS20063
HPRD
IMGT
MGI ID MGI:1923513
MGI Symbol Gstk1
EMBL AK002661 AY279096 BC058163
GenPept AAH58163 AAP20655 BAB22268
RNA Seq Atlas 76263

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca