Homo sapiens Gene: ADAM10
Summary
InnateDB Gene IDBG-14155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM10
Gene Name ADAM metallopeptidase domain 10
Synonyms AD10; AD18; CD156c; HsT18717; kuz; MADM; RAK;
Species Homo sapiens
Ensembl Gene ENSG00000137845
Encoded Proteins
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
ADAM metallopeptidase domain 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ADAM10 associates with tetraspanins and regulates cleavage of TNF (TNF-alpha) and EGF (epidermal growth factor).
Entrez Gene
Summary Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:58588807-58749978
Strand Reverse strand
Band q21.3
Transcripts
ENST00000260408 ENSP00000260408
ENST00000396136 ENSP00000456542
ENST00000402627 ENSP00000386056
ENST00000439637 ENSP00000391930
ENST00000482945
ENST00000470269
ENST00000462061
ENST00000481164
ENST00000475898
ENST00000497846
ENST00000461408 ENSP00000481779
ENST00000561288 ENSP00000452639
ENST00000559053 ENSP00000453952
ENST00000558733
ENST00000558004 ENSP00000452704
ENST00000560608
ENST00000561149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007162 negative regulation of cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0008219 cell death
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0045087 innate immune response (InnateDB)
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 constitutive protein ectodomain proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
GO:0097197 tetraspanin-enriched microdomain
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
REACTOME
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Developmental Biology pathway
Signaling by EGFR in Cancer pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Extracellular matrix organization pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by EGFR pathway
Degradation of the extracellular matrix pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Axon guidance pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH4 pathway
Signal Transduction pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH3 pathway
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
EPH-Ephrin signaling pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Collagen degradation pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
Alzheimer's disease pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
Notch signaling pathway pathway
PID BIOCARTA
Generation of amyloid b-peptide by ps1 [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Posttranslational regulation of adherens junction stability and dissassembly
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 102
UniGene Hs.172028 Hs.578508 Hs.594928
RefSeq NM_001110
HUGO HGNC:188
OMIM 602192
CCDS CCDS10167
HPRD 03723
IMGT
EMBL
GenPept
RNA Seq Atlas 102