Bos taurus Gene: ADAM10
Summary
InnateDB Gene IDBG-646594.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM10
Gene Name Disintegrin and metalloproteinase domain-containing protein 10
Synonyms ADAM 10;
Species Bos taurus
Ensembl Gene ENSBTAG00000005481
Encoded Proteins
Disintegrin and metalloproteinase domain-containing protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ADAM10 associates with tetraspanins and regulates cleavage of TNF (TNF-alpha) and EGF (epidermal growth factor).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137845:
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:51598073-51739153
Strand Forward strand
Band
Transcripts
ENSBTAT00000044627 ENSBTAP00000042110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007162 negative regulation of cell adhesion
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 constitutive protein ectodomain proteolysis
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
GO:0097197 tetraspanin-enriched microdomain
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Extracellular matrix organization pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Collagen degradation pathway
Degradation of the extracellular matrix pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
EPH-Ephrin signaling pathway
Signaling by NOTCH3 pathway
Signaling by NOTCH1 in Cancer pathway
Signal Transduction pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Axon guidance pathway
Signaling by NOTCH1 pathway
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH4 pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH2 pathway
Disease pathway
Developmental Biology pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Developmental Biology pathway
Signaling by EGFR in Cancer pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Extracellular matrix organization pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by EGFR pathway
Degradation of the extracellular matrix pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Axon guidance pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH4 pathway
Signal Transduction pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH3 pathway
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
EPH-Ephrin signaling pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Collagen degradation pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Disease pathway
Extracellular matrix organization pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by EGFR pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH3 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
EPH-Ephrin signaling pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH4 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Axon guidance pathway
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Developmental Biology pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Signaling by EGFR in Cancer pathway
Degradation of the extracellular matrix pathway
Collagen degradation pathway
KEGG
Alzheimer's disease pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Alzheimer's disease pathway
INOH
Notch signaling pathway pathway
Notch signaling pathway pathway
PID BIOCARTA
Generation of amyloid b-peptide by ps1 [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Posttranslational regulation of adherens junction stability and dissassembly
Notch signaling pathway
Cross-References
SwissProt Q10741
TrEMBL
UniProt Splice Variant
Entrez Gene 282132
UniGene Bt.49218
RefSeq NM_174496
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153863 Z21961
GenPept AAI53864 CAA79973
RNA Seq Atlas 282132
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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