InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cldn5

Summary

InnateDB Gene

IDBG-142207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn5

Gene Name

claudin 5

Synonyms

AI854493; MBEC1; Tmvcf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041378

Encoded Proteins

IDBP-142209

claudin 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:18776847-18778260

Strand

Forward strand

Band

Transcripts

ENSMUST00000043577

ENSMUSP00000041925

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0016338	calcium-independent cell-cell adhesion
GO:0042552	myelination

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0033270	paranode region of axon
GO:0043220	Schmidt-Lanterman incisure
GO:0070062	extracellular vesicular exosome