Version 5.4
Homo sapiens Gene: CLDN5
Summary
InnateDB Gene IDBG-1386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN5
Gene Name claudin 5
Synonyms AWAL; BEC1; CPETRL1; TMVCF
Species Homo sapiens
Ensembl Gene ENSG00000184113
Encoded Proteins
IDBP-292500
claudin 5
IDBP-292501
claudin 5
IDBP-361928
claudin 5
IDBP-809170
claudin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:19523024-19527545
Strand Reverse strand
Band q11.21
Transcripts
ENST00000406028 ENSP00000385477
ENST00000403084 ENSP00000384554
ENST00000413119 ENSP00000400612
ENST00000618236 ENSP00000480623
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0042552 myelination
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0033270 paranode region of axon
GO:0043220 Schmidt-Lanterman incisure
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041378
View Gene Order
ENSBTAG00000022020
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.505337
RefSeq NM_001130861 NM_003277 XM_005261272
HUGO
OMIM
CCDS CCDS13763
HPRD 03654
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca