Homo sapiens Gene: NRXN3
Summary
InnateDB Gene IDBG-14238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRXN3
Gene Name neurexin 3
Synonyms C14orf60;
Species Homo sapiens
Ensembl Gene ENSG00000021645
Encoded Proteins
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
neurexin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:78242391-79868290
Strand Forward strand
Band q24.3
Transcripts
ENST00000335750 ENSP00000338349
ENST00000281127 ENSP00000281127
ENST00000428277 ENSP00000394426
ENST00000554738 ENSP00000450683
ENST00000556088
ENST00000553363 ENSP00000451754
ENST00000553631 ENSP00000451947
ENST00000554719 ENSP00000451648
ENST00000556496
ENST00000557081 ENSP00000450462
ENST00000557594 ENSP00000451672
ENST00000555387 ENSP00000451393
ENST00000555073
ENST00000553803
ENST00000556003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
GO:0097109 neuroligin family protein binding
Biological Process
GO:0001525 angiogenesis
GO:0007158 neuron cell-cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007612 learning
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0051965 positive regulation of synapse assembly
GO:0071625 vocalization behavior
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368307 Hs.627999 Hs.715668
RefSeq NM_001105250 NM_001272020 NM_004796 NM_138970
HUGO
OMIM
CCDS CCDS45145 CCDS61515 CCDS9870 CCDS9871
HPRD 08989
IMGT
EMBL
GenPept
RNA Seq Atlas