|Homo sapiens Gene: NRXN3|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||neurexin 3|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
|Genomic Location||Chromosome 14:78242391-79868290|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Cell adhesion molecules (CAMs) pathway
|UniProt Splice Variant|
|UniGene||Hs.368307 Hs.627999 Hs.715668|
|RefSeq||NM_001105250 NM_001272020 NM_004796 NM_138970|
|CCDS||CCDS45145 CCDS61515 CCDS9870 CCDS9871|
|RNA Seq Atlas|