Mus musculus Gene: Wrnip1
InnateDB Gene IDBG-142427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wrnip1
Gene Name Werner helicase interacting protein 1
Synonyms 4833444L21Rik; WHIP; Wrnip
Species Mus musculus
Ensembl Gene ENSMUSG00000021400
Encoded Proteins
Werner helicase interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124535:
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:32802038-32822609
Strand Forward strand
Band A3.2
ENSMUST00000021832 ENSMUSP00000021832
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042802 identical protein binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0030174 regulation of DNA-dependent DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q91XU0
UniProt Splice Variant
Entrez Gene 78903
UniGene Mm.286680 Mm.400612
RefSeq NM_030215
MGI ID MGI:1926153
MGI Symbol Wrnip1
EMBL AB056151 AF208046 AK041886 AK050368 AK082078 AK167570 AK170542 AK170846 AL645808 BC010482 BC058744
GenPept AAG35725 AAH10482 AAH58744 BAB60708 BAC31091 BAC34213 BAC38404 BAE39633 BAE41868 BAE42069 CAI25647
RNA Seq Atlas 78903