InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wrnip1

Summary

InnateDB Gene

IDBG-142427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wrnip1

Gene Name

Werner helicase interacting protein 1

Synonyms

4833444L21Rik; WHIP; Wrnip

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021400

Encoded Proteins

IDBP-142429

Werner helicase interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124535:
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:32802038-32822609

Strand

Forward strand

Band

A3.2

Transcripts

ENSMUST00000021832

ENSMUSP00000021832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042802	identical protein binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030174	regulation of DNA-dependent DNA replication initiation

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000124535

View Gene Order

ENSBTAG00000006166

Not yet available

Cross-References

SwissProt

Q91XU0

TrEMBL

UniProt Splice Variant

Entrez Gene

78903

UniGene

Mm.286680 Mm.400612

RefSeq

NM_030215

OMIM

CCDS

CCDS26427

HPRD

IMGT

MGI ID

MGI:1926153

MGI Symbol

Wrnip1

EMBL

AB056151 AF208046 AK041886 AK050368 AK082078 AK167570 AK170542 AK170846 AL645808 BC010482 BC058744

GenPept

AAG35725 AAH10482 AAH58744 BAB60708 BAC31091 BAC34213 BAC38404 BAE39633 BAE41868 BAE42069 CAI25647

RNA Seq Atlas

78903